Warner Bros. cartoons made fun of pop culture for years (though, by the ‘50s, the gags were a little tired). This is from “A Gander at Mother Goose,” released in 1940. The big bad wolf is going through the usual scene when the pigs call a halt and hand him a bottle.
The bottle of Histerine is a stand-in for Listerine, whose ad pitch reminded people even their best friends don’t tell them about bad breath. Other than the pre-Bugs Bunny eagle that says “Doc” and Jack Be Nimble sounding like a future wabbit, there sure isn’t much else to interest anyone in this cartoon. Even Sara Berner couldn’t be bothered to throw in a “Rally I am” in her Kate Hepburn impression as Mary, Mary, Quite Contrary. There’s a dog/tree gag and a bare butt gag for those of you keeping track of when Tex Avery used them.
Chuck McKimson gets the animation credit here but I suspect Irv Spence and Virgil Ross are in here, too.